Corrie daCosta

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Corrie daCosta
Assistant Professor

FSS 15007

Office: 613-562-5800 ext. 2546

Work E-mail: cdacosta@uOttawa.ca

Photo of Corrie DaCosta

Biography

Dr. daCosta examines structure-function relationships in a class of proteins called ligand-gated ion channels, which are ion-conducting pores embedded in cell membranes.  Evolved to convert chemical signals into electrical impulses, ligand-gated ion channels mediate fundamental physiological processes, are implicated in numerous human diseases, and are the targets of a wide variety of drugs.  Dr. daCosta seeks to both control ligand-gated ion channel function with chemistry, and to engineer ligand-gated ion channels with unique and useful properties.

Selected publications

  • Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors. daCosta CJ, Free CR, Sine SM. Nature Communications. 2015 Aug 18; 6:8057 doi: 10.1038/ncomms9057.
  • A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors. daCosta CJ, Dey L, Therien JP, Baenziger JE.Nature Chemical Biology. 2013 Nov;9(11):701-7.
  • Stoichiometry for drug potentiation of a pentameric ion channel. daCosta CJ, Sine SM. PNAS. 2013 Apr 16;110(16):6595-600.
  • Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM. The Journal of Neuroscience. 2011 Sep 28;31(39):13870-9.

For a full list of publications visit Pubmed.

Fields of Interest

  • Chemical biology
  • Protein structure and function
  • Single-molecule experiments
  • Ion channels
  • Electrophysiology
  • Biochemistry
  • Biophysics
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