Office: 613-562-5800 ext. 2546
Work E-mail: cdacosta@uOttawa.ca
Dr. daCosta examines structure-function relationships in a class of proteins called ligand-gated ion channels, which are ion-conducting pores embedded in cell membranes. Evolved to convert chemical signals into electrical impulses, ligand-gated ion channels mediate fundamental physiological processes, are implicated in numerous human diseases, and are the targets of a wide variety of drugs. Dr. daCosta seeks to both control ligand-gated ion channel function with chemistry, and to engineer ligand-gated ion channels with unique and useful properties.
- Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors. daCosta CJ, Free CR, Sine SM. Nature Communications. 2015 Aug 18; 6:8057 doi: 10.1038/ncomms9057.
- A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors. daCosta CJ, Dey L, Therien JP, Baenziger JE.Nature Chemical Biology. 2013 Nov;9(11):701-7.
- Stoichiometry for drug potentiation of a pentameric ion channel. daCosta CJ, Sine SM. PNAS. 2013 Apr 16;110(16):6595-600.
- Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM. The Journal of Neuroscience. 2011 Sep 28;31(39):13870-9.
For a full list of publications visit Pubmed.