Par Prof. Sachiko Sato, Centre de recherche sur les maladies infectieuses, CRCHU de Québec, Faculté de médecine, Université Laval, Canada
Quand : Mercredi 16 octobre 2019 at 11:30 am
Où : Pavillon D'Iorio, pièce 214
Ce séminaire est présenté en anglais uniquement.
The cell surface of any living organism is covered by thick sugar layers (~140nm), called glycocalyx. Thus, any molecules, microorganisms, or cells first encounter the glycocalyx before they physically interact with the target molecules or cells. Many biological regulations are directly or indirectly regulated by the interaction between oligo (or poly)-saccharides in the glycocalyx and sugar-binding proteins, lectins. In this talk, I will talk about our journey to understand the role of a lectin, called galectin-3 or Mac-2 in infectious diseases and muscular dystrophy. In the first part, I will briefly talk on the role of galectin-3 in the early migration of neutrophils to the site of infection. In the second part, I would like to present our recent results suggesting that a monosaccharide, N-acetylglucosamine increases myogenesis and the force production of muscle of Duchenne muscular dystrophy by augmenting the interaction between galectin-3 and its oligosaccharide ligands. Our findings raise the exciting therapeutic possibility that N-acetylglucosamine might be used as a therapy to mitigate the progression of the muscular dystrophy.